Design, synthesis and validation of bioactive compounds
Welcome to the LifeArc Chemistry Job Simulation! We are thrilled to have you here.
The Chemical Biology team focuses on the design and synthesis of drug-like molecules for the treatment of various diseases.
During this programme, you will get the opportunity to step into the shoes of a LifeArc associate scientist and complete tasks that replicate the work that our Chemical Biology team does every day. You’ll gain knowledge and skills in:
– Designing and synthesising bioactive compounds
– Interpreting data from biochemical validation experiments
– Communicating project findings
We hope this programme provides a great resource for you to enhance and strengthen your CV as you explore career options and a potential career at LifeArc.
This program is self-paced. It takes approximately 5-6 hours to complete.
Skills Learned:
- Intro & Scenario
Background context and your project team - Designing a range of PROTACs against a cancer protein
Designing PROTAC candidates- Chemical Reasoning
- Drug-Like Molecule Design
- Experimental Design
- Chemistry Drawing Software
- Sketching out a synthesis route for a PROTAC molecule using click chemistry
PROTAC synthesis using click chemistry- Click Chemistry
- Drug-Like Molecule Synthesis
- Experimental validation of PROTACs
Validation of candidate PROTACs- Experimental Data Interpretation
- Research Communication
- Presentation of results
Final presentation- Data Interpretation
- Research Presentation Skills
- Slide Deck Preparation
- Finish Line
